Saddest videogame moments

[puggsoy]

I thought this would be an interesting idea for a thread. So yeah, post the saddest moments you've experienced in a video game.
I'm sure that numerous of these will be near the end of the game, and if that's so then be sure to put any comments/videos/pictures about it in a spoiler, with the name of the game you're talking about.

OBS: MAKE USE OF THE SPOILERS TO TALK ABOUT ENDGAME AND/OR OTHER IMPORTANT STUFF.

Professor Layton and the Unwound Future

This scene is the absolute saddest I've seen, not only in gaming but anywhere. Never has any movie or other form of media made my eyes truly well up with tears, but this certainly did. I know that's nerdy, but knowing how gentlemanly the professor is, and how much self control he has, his reactions in this bit are absolutely heart wrenching.
Even now, more than a year after initially watching it, my stomach lurches with the sadness in this scene. I still feel deeply for both Claire and Hershel, despite them being fictional.
I know, I'm way too emotional for a guy.

The cutscene in question starts at 3:28.

*sniff*